Stress Physiology Lab

Rodent studies are focused on:

• Epigenetic and cellular mechanisms underlying the pathophysiology of cardiovascular dysfunction in rats of both sexes exposed to social stress paradigms.
• Systemic and peripheral FAAH inhibition as a potential pharmacological strategy for stress-induced anxiety and depression-like disorders.
  

Human studies are centered on:

1. Psychobiological evaluation of the efficacy of EMDR (eye movement desensitization and reprocessing) and mindfulness as stress resilience strategies;
   
2. Evaluation of the relationship between gut microbiota and physiological/behavioral signs of chronic stress and/or anxiety/depression;
   
3. Development of IoT (Internet of Things) systems for the psychophysiological monitoring of stress in car drivers;
   
4. Evaluation of the relationship between individual behavioral profiles and stress levels in surgeons;
   
5. Investigation on the role of psychosocial stress as etiopathogenetic mechanism in acute coronary syndromes.

Carnevali L., Barbetti M., Statello R., Williams DP., Thayer JF., Sgoifo A. 2023. Sex differences in heart rate and heart rate variability in rats: Implications for translational research. Front. Physiol., 14:1170320. doi: 10.3389/fphys.2023.1170320.

Carnevali L., Bignami E., Gambetta S., Barbetti M., Procopio M., Freyrie A., Carbognani P., Ampollini L., Sgoifo A. 2023. Cardiac autonomic and cortisol stress responses to real operations in surgeons: relationship with individual psychobiological characteristics and experience. Biopsychosoc Med., 17:5. doi: 10.1186/s13030-023-00266-5.

Barbetti M., Vilella R., Dallabona C., Gerra MC., Bocchi L., Ielpo D., Andolina D., Sgoifo A., Savi M., Carnevali L. 2022. Decline of cardiomyocyte contractile performance and bioenergetic function in socially stressed male rats. Heliyon, 8: e11466. doi: 10.1016/j.heliyon.2022.e11466.

Makovac E., Carnevali L., Medina S., Sgoifo A., Petrocchi N., Ottaviani C.  2022. Safe in my heart: resting heart rate variability longitudinally predicts emotion regulation, worry, and sense of safeness during COVID-19 lockdown. Stress, 25:9-13. doi: 10.1080/10253890.2021.1999408.

Davoli L., Mattioli V., Gambetta S., Belli L., Carnevali L., Martalo M., Sgoifo A., Raheli R., Ferrari G. 2021. Non-invasive psycho-physiological driver monitoring through IoT-oriented systems. In book: The Internet of Medical Things: Enabling technologies and emerging applications (pp.19-33) 2021. doi: 10.1049/PBHE034E_ch2

Statello R., Carnevali L., Sgoifo A., Miragoli M, Pisani F. 2021. Heart rate variability in neonatal seizures: Investigation and implications for management. Neurophysiol Clin., 51:483-492. doi: 10.1016/j.neucli.2021.10.002.

Andolina D., Savi M., Ielpo D., Barbetti M., Bocchi L., Stilli D., Ventura R., Lo Iacono L., Sgoifo A., Carnevali L. 2021. Elevated miR-34a expression and altered transcriptional profile are associated with adverse electromechanical remodeling in the heart of male rats exposed to social stress. Stress. 24:621-634. doi: 10.1080/10253890.2021.1942830.

Carnevali L., Cerritelli F., Guolo F., Sgoifo A. 2021. Osteopathic Manipulative Treatment and Cardiovascular Autonomic Parameters in Rugby Players: A Randomized, Sham-Controlled Trial. J Manipulative Physiol Ther, 44:319-329. doi: 10.1016/j.jmpt.2020.09.002.

Carnevali L., Statello R., Vacondio F., Ferlenghi F., Spadoni G., Rivara S., Mor M., Sgoifo A. 2020. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. Eur Neuropsychopharmacol., 32: 77-87. doi: 10.1016/j.euroneuro.2019.12.119.